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Suitable for all sizes, simply cut it to fit the animal`s neck. Once opened it is effective for up to 6 weeks and is water resistant. INSTRUCTIONS FOR USE: apply on the dog`s neck 1 vial every 2 days in the moment of greatest need, and 1 vial every 3/4 weeks for maintenance. A constant and regular use enhances the effectiveness. Neem oil as a valuable aid For animals, Neem Oil represents a valid support for the natural defenses especially in the summer periods when the animal`s skin is more subject to being targeted by infestations of external origin. Particularly suitable for puppies, elderly animals, convalescing, pregnant and lactating animals and animals in contact with children. Niki Natural Defense products can be used alone or in combination with other products.